It seems to me that the biggest problem facing the advancement of the Wingnut political agenda is going to be top leadership. In order to transcend regional strength, the Wingnut coalition nationally must field leader/statesmen who can take on a mantle of populism that can rally more groups than just the base.
John McCain attempted this feat. Guys like Mitt Romney and Rick Santorum are eager to try. Where they run into trouble is that as soon as they try to move a little bit toward the center, the base starts to criticize and if they stand firm on issues dear to the base, abortion, homophobia, abolishing public education and health care, independent voters of normal intelligence shy away.
It doesn't help that likely candidates for national Republican leadership, do not personally believe the right way on at least some of the major social issues that bind the Republican coalition together. Many are secretly non homophobes, themselves gay or even worse, heterosexuals who are enthusiastic fornicators , inclined toward big spending, not particularly religious, uninterested in preserving preborn life, secret tree huggers or guilty of any one of a hundred sins that militant Wingnuttery loathes.
I can't think of a single person that could run for President on the Republican ticket in 2012 that would be both acceptable to the base and capable of bringing enough independents on board to gain the needed support to win.